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As for other AntiVirus Solutions it's often necessary to make exclusions in Windows Defender AntiVirus and stop defrag if enable.
To determine if Microsoft Defender is installed on your server you can check this by checking the installed features on this Windows Server 2016:
By using the command "
sc query Windefend" you can also determine if the Windows Defender Service is installed.
If you trust a file, file type, folder, or a process that Windows Defender Antivirus and Defrag has detected as malicious, you can stop Windows Defender Antivirus/Defrag from alerting you or blocking the program by adding the file to the exclusions list.
If you want to find out how you can refer to this Microsoft link: https://support.microsoft.com/en-us/help/4028485/windows-10-add-an-exclusion-to-windows-defender-antivirus
Disable Defrag: https://superuser.com/questions/1210453/windows-10-disable-automatic-defragmentation
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